Aller-Sine by Vaxa

Why wait for the sneezing and sniffling to start? Aller-Sine contains homeopathic medicinals that have been shown to:

1. Help stop the release of histamines causing your stuffed up nose and runny eyes
2. Help counter the drowsiness caused by Serotonin release
3. Help diminish associated pain and inflammation

Aller-Sine is a Scientifically Advanced homeopathic medicinal formula providng highly specific nutrients which complement the body's natural ability to effectively reduce the overabundance of Histamine and other inflammatory cytotoxic substances within the body, while also inhibiting the allergic reactions to drugs/serums, pollen, dust, animal fur and other environmental pollutants.

Suggested Usage: 60 capsules per bottle. Take 3 capsules daily for maintenance. For more severe problems with allergies, take 3 capsules every 2 hours, or as directed by a physician.

The ingredients for Aller-Sine : DL-Methionine, Potassium Citrate, Ginkgo Biloba, White Willow Bark, DL-Phenylalanine, L-Glutathione, White Pine Bark Extract, Magnesium, L-Lysine HCL, Pyridoxine HCL-B6, Folic Acid, Cobalamin-B12, Homeopathics:, Adrenalinum, Euphrasia officinalis, Histaminum, Nux vomica, Kali chloricum, Sabadilla, Thyroidinum, Nettle, Ambrosia Artemisiafolia, Echinacea, Euphorbium Offcinarum, Hydrastis Canadensis, Kali Iodatum, Ledume Palustre, Sanguinaria Canadesis, Sulphur, Thuja Occidentalis, Mercuric Solubilis, VITAMIN C, Urtica Dioica,

How Is Aller-Sine Different From Other Over-the-Counter (anti-histamines) Hayfever Medicines?
Most allergies result from an overabundance of Histamines and other cytotoxic substances being released into the body. These substances cause all the symptoms of allergies, such as the runny nose, the incessant sneezing, itching and watery eyes which are common for most of us. Greater amounts of these substances mean more severe allergies, and less amounts mean little or no allergic reaction. But Histamine is the main culprit. Whereas all over-the-counter medications are "Anti-Histamines," which only mask or cover up the Histamines once released, Aller-Sine seeks to stop Histamines from being released in the first place! Aller-Sine acts with the body to inhibit the rupturing of mast cells and basophils, from which Histamine is released. Thus, unlike ordinary "Anti-Histamines," Aller-Sine doesn't "wait" for the Histamine to be released before it goes to work. Instead, the nutrients seek to naturally shut the proverbial "barn door" before the Histamines are released. In this way, most, if not all, of the allergic reaction is circumvented and thus prevented.

The cause of most Allergy symptoms:
an actual enhanced micrograph of a Mast Cell rupturing and releasing its Histamines(stained red globules), Serotonin and other prostaglandins into the blood stream, causing the typical allergic reactions of Allergies, Hayfever and Sinusitis.

What Are Allergies & Why Do We Experience Them?
Allergies are abnormal or hypersensitive responses of the Immune System to relatively harmless environmental antigens (substance which causes the allergy). In general, there are two broad types of Allergies:

1) Allergy caused by excess IgE Antibodies (Type I): Most immediate allergic reactions involve antigen-antibody reactions, mainly with the antibody protein, "IgE." Allergic individuals who experience moderate to severe allergy problems may have higher than normal levels of serum IgE and an increased number of high affinity IgE/Fc-receptors (the actual docking sites of IgE) on their basophils (located in the blood supply) and mast cells (within the connective tissue, generally located immediately outside the small blood vessels). Thus, the more IgE and IgE/Fc-receptors a person has, the more probable the allergic reaction, and the more severe that reaction will be. In these cases, the reacting IgE antibodies have a peculiar attraction to bind to IgE/Fc-receptor sites on mast cells and basophils, which in turn are responsible for releasing Histamines and other inflammatory substances into the body, creating the many allergic reactions with which we are all familiar. Specifically, with the occurance of an antigen (allergen) reacting or binding to IgE antibodies, the IgE antigen-antibody molecule then "docks" on the Fc-receptors of mast cells and basophils, causing IgE cross-linking and subsequent receptor clustering on the cell membrane. This docking, in turn, causes an immediate change in the membrane of the mast cell or basophils, either causing it to rupture (called cell granulation) or simply secrete a torrent of pharmacologically active substances including Histamine, 5-Hydroxytryptamine (Serotonin) and other inflammatory substances into the bloodstream, all of which cause the known allergic reactions we hate.

2) Allergy caused by Over-Activated T-Cells (Type II): Most other allergic reactions (delayed-reaction allergies) are caused by the over-activation of T-Cells (helper cells and cytotoxic "killer"cells, in particular) and not by IgE antibodies themselves. Examples of this type of allergy are that of the skin's eruption caused by the toxins in poison ivy or a bee sting, asthmatic attacks when muscle spasms result from the case of some air-borne antigens, or even the allergic reaction one may experience from vaccines. On repeated exposure to these antigens, activated "killer" T-Cells are formed. Then, on subsequent exposure to the toxin, these T-Cells move into affected tissues to respond, eliciting a cell-mediated type of immune reaction which may cause more damage to surrounding tissue than the original toxin/antigen did. This is because over-activated "killer" T-Cells can kill normal body cells in these reactions, and cause basophil and mast cell rupturing. In all cases of allergy (Type I and II), however, Histamines and cytotoxic substances are released from mast cells and basophils which result in the typical allergic responses.

What Happens When Histamine Is Released Into My Body? Histamine is a neurotransmitter which directly causes a biphasic response of vasoconstriction followed by peripheral vessel dilation. The release of Histamine has a wide range of effects, which include capillary dilatation, contraction of smooth muscle, increased gastric acid secretion, and acceleration of heart rate.

How Does Aller-Sine Specifically Work? DL-Methionine, L-Lysine, bioflavonids in white pine bark, and other micro-nutritionals within Aller-Sine help the body stabilize mast cell and basophil integrity by naturally regulating the sensitivity of IgE, and perhaps even the number of IgE that the body makes, keeping the histamines and cytoxic substances from being released into the body. micro-nutritionals in Aller-Sine also act to stimulate the adrenals and thyroid while redirecting and strengthening the immune and lymphatic responses, and to help the body naturally regulate adrenal production of cortocosteroids which exhibit immunosuppressive (T-Cell management) and anti-inflammatory activity. Cortocosteroids are thought to act chiefly by blocking the release of cytokines (intercellular signals, usually protein or glycoprotein, involved in the regulation of cellular proliferation and function) from activated mononuclear phagocytes and mast cells, and possibly also by the direct lysis of immature T-Cells, thus affecting mast cell stability and the subsequent release of unwanted histamines.

Methionine is also the most commonly used amino acid (codon=AUG) which initiates protein synthesis from mRNA-DNA transcription and decoding. Thus, when Methionine stores are in scant supply, protein synthesis is delayed, directly interfering with Corticosteroid production, which, because of these molecules' immunosuppressive and anti-inflammatory activities, may in turn exacerbate any ongoing allergic reaction within the body. With ample supplies of DL-Methionine, as provided by Aller-Sine, the adrenals can increase natural steroid production and maintain corticosteroid populations, thus keeping in check the Immune System's sensitivities to foreign bodies, as well as getting rid of any rogue T-Cells, which could inappropriately sound the alarm and cause an unneeded allergic response. Thus, Aller-Sine addresses all the known problems of allergies (Type I & II), providing fast relief without the side-effects of drowsiness, lethargy or sleepiness associated with most other products.